Chenopodium Quinoa's Ingredients Contribute to the Gut Microbiota's Metabolic Adaptations on Carbohydrate Metabolism

Gut microbiota dysbiosis significantly contributes either to metabolic or immune diseases. Modulating the gut microbiome is the subject of intense research, but how immunonutritional ingredients from Chenopodium quinoa contribute to shaping the commensal microbiome and its metabolic capacities has not been determined. Sixty healthy volunteers participated in a double-blind, randomized parallel pilot study with two study arms: high fat-containing cookie and a C. quinoa-based cookie. The composition of the colonic microbiota was quantified by real time qPCR and bacterial metabolism to use carbohydrates was monitored using metabolic strips. Regardless of the order in which the volunteers receive the cookies, the administration of the C. quinoa-based cookie allows establishing and maintaining significant differences in the diversity of the microbiota. C. quinoa-based cookie prevented imbalances in the gut microbiota composition derived from the administration of the high fat-containing cookie. These findings provide new insights into how immunonutritional foods can help to establish steady-state commensalism.