The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Upregulated circular RNA (circRNA) expression is linked to poorer outcomes in acute myeloid leukemia (AML) patients. These findings suggest circRNAs could be valuable biomarkers for predicting AML prognosis, especially in intermediate-risk cases.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Current methods for assessing acute myeloid leukemia (AML) patient prognosis, such as cytogenetic and molecular analysis, have limitations, particularly for intermediate-risk cases.
- Biomarkers for accurately predicting prognosis in intermediate-risk AML patients are needed to refine treatment strategies and improve patient outcomes.
- Circular RNAs (circRNAs) are emerging as potential regulators in various cancers, but their prognostic role in AML requires further elucidation.
Purpose Of The Study
- To conduct a meta-analysis evaluating the association between circRNA expression and prognosis in acute myeloid leukemia (AML).
- To identify potential circRNA biomarkers for predicting prognosis, especially in intermediate-risk AML patients.
- To provide a scientific basis for updating clinical guidelines, such as WHO practice guidelines and European LeukemiaNet (ELN) risk classification.
Main Methods
- A comprehensive literature search was conducted across PubMed, Cochrane Library, and Web of Science databases up to September 15, 2024.
- Included studies were assessed for quality using the Newcastle-Ottawa Scale (NOS).
- Hazard ratios (HR) and 95% confidence intervals (CI) for overall survival (OS) and event-free survival (EFS) were pooled using STATA 17.0 software.
Main Results
- The meta-analysis included 13 studies with a total of 1401 AML patients.
- Upregulated circRNA expression was significantly associated with increased hazard for overall survival (HR=1.87, 95% CI=1.51-2.32, P<0.001).
- Subgroup analyses revealed a significant increase in hazard ratio for upregulation of circRNA expression in event-free survival (HR=1.66, 95% CI=1.19-2.32, P<0.005) and specifically for circ_0012152 (HR=2.26, 95% CI=1.27-4.00, P<0.005).
Conclusions
- Elevated circRNA expression is significantly correlated with a poorer prognosis in patients with acute myeloid leukemia (AML).
- CircRNAs demonstrate potential as reliable prognostic markers for AML.
- Further research focusing on the prognostic impact of circRNAs in AML is warranted to refine risk stratification and clinical management.
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