Using a sensitive screen-printed electrode based on printex L6 and polyaniline activated carbon for piroxicam...

Area of Science:

• Electrochemistry
• Analytical Chemistry
• Materials Science

Background:

• Piroxicam (PIR) detection in biological and environmental samples requires sensitive and efficient methods.
• Existing analytical techniques may be complex, time-consuming, or costly.
• Development of novel sensors is crucial for accurate and accessible Piroxicam quantification.

Purpose of the Study:

• To develop a straightforward, rapid, and cost-effective voltammetric technique for Piroxicam (PIR) detection.
• To create an enhanced screen-printed electrode (SPE) for improved sensitivity and selectivity.
• To validate the proposed method for PIR analysis in complex matrices like biological and environmental samples.

Main Methods:

• Fabrication of a modified screen-printed electrode (SPE) using Printex L6 carbon (PL6C), polyaniline-based activated carbon (PAC), and chitosan film crosslinked with epichlorohydrin (CTS:EPH).
• Detection of Piroxicam using square-wave adsorptive anodic stripping voltammetry (SWAdASV) in a phosphate buffer solution (0.10 mol L⁻¹ , pH 6.0).
• Validation of the sensor's performance through limit of detection, linear range determination, and recovery tests in synthetic urine and river water.

Main Results:

• The developed PAC-PL6C-CTS:EPH/SPE sensor achieved a low limit of detection of 4.5 × 10⁻⁹ mol L⁻¹ for Piroxicam.
• A wide linear range (5.0 × 10⁻⁸ to 8.8 × 10⁻⁶ mol L⁻¹) with excellent linearity (r = 0.999) was observed.
• The sensor demonstrated high reliability and accuracy in detecting Piroxicam in synthetic urine and river water samples, with results comparable to HPLC.

Conclusions:

• The proposed voltammetric technique offers a simple, rapid, and cost-effective method for Piroxicam detection.
• The modified screen-printed electrode (PAC-PL6C-CTS:EPH/SPE) shows significant potential for Piroxicam quantification in diverse matrices.
• This approach provides a viable alternative to conventional methods for Piroxicam analysis in both biological and environmental monitoring.