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  11. Upgrading Skin Barrier Protection: Addition Of Active Ingredients To A Gelatin/tannic Acid-based Hydrogel Patch For Treating Skin Lesions Related To Personal Protective Equipment

Upgrading skin barrier Protection: Addition of active ingredients to a Gelatin/Tannic Acid-Based hydrogel patch for treating skin lesions related to Personal protective Equipment

Angélica Graça1, Catarina Pereira1, Ana M Martins1

  • 1Research Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.

International Journal of Pharmaceutics
|December 21, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

New hydrogel patches offer skin protection and treatment for mask-related issues like "maskne" and rosacea. These dual-function patches improve skin health during prolonged personal protective equipment use.

Area of Science:

  • Materials Science
  • Dermatology
  • Pharmaceutical Sciences

Background:

  • Prolonged use of personal protective equipment (PPE), such as surgical masks, frequently leads to adverse skin reactions including acne mechanica ("maskne") and exacerbations of rosacea.
  • Existing skin protectants may compromise mask efficacy or lack therapeutic agents for common dermatological conditions.

Purpose of the Study:

  • To develop and characterize an innovative dual-function hydrogel patch for simultaneous skin protection and treatment of mask-induced dermatoses.
  • To incorporate therapeutic agents, metronidazole or salicylic acid, into a gelatin/tannic acid-based hydrogel system.

Main Methods:

  • Hydrogel formulations (gelatin/tannic acid, with metronidazole or salicylic acid) were characterized for thermal properties, mechanical strength (burst strength, extensibility, adhesivity), and tribological behavior.
Keywords:
Hydrogel patchIn vitro releaseRheologyTannic acid

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  • In vitro drug release kinetics were assessed using Franz diffusion cells under occlusive conditions to simulate real-world mask application.

    • Main Results:

    • Both metronidazole and salicylic acid formulations exhibited favorable gelation temperatures and enhanced adhesivity and extensibility, proving suitable for diverse skin types.
    • Metronidazole addition significantly boosted hydrogel burst strength, indicating improved mechanical integrity.
    • In vitro release studies demonstrated an initial rapid drug release followed by sustained release, unaffected by simulated mask occlusion.

    Conclusions:

    • Dual-function gelatin/tannic acid hydrogel patches effectively protect the skin while delivering therapeutic agents.
    • These novel patches present a promising solution for managing and preventing skin conditions arising from prolonged mask usage, such as "maskne" and rosacea.
    Texture analysis