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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Retinal microvascular dysfunction in systemic sclerosis.

Natallia Laptseva1, Konstantinos Bitos1, Valentina A Rossi2

  • 1Department of Cardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.

Microvascular Research
|December 21, 2024
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) patients exhibit impaired retinal microvascular function, as revealed by retinal vessel analysis. This dysfunction correlates with disease duration, suggesting potential for prognostic assessment.

Keywords:
Cardiovascular riskDynamic retinal vessel analyzerEndothelial dysfunctionRetinal vesselsSystemic sclerosisVasculature

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Cardiovascular Research

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease marked by microvasculopathy and fibrosis.
  • Vascular and endothelial cell changes are early indicators in SSc.
  • Retinal vascular analysis offers a novel method for assessing microvascular function.

Purpose of the Study:

  • To investigate retinal microcirculation in SSc patients compared to healthy controls.
  • To assess the utility of retinal microvascular function as a biomarker in SSc.

Main Methods:

  • Non-invasive assessment of flicker-light induced vasodilation of retinal arterioles (FIDart%) and venules.
  • Measurements included central retinal arteriolar and venular equivalents (CRAE, CRVE), brachial artery flow-mediated dilation (FMD), and pulse wave velocity (PWV).
  • 40 SSc patients were compared with 40 age- and sex-matched healthy controls (HC).

Main Results:

  • SSc patients demonstrated significantly impaired retinal microvascular function (FIDart%: 2.23 ± 2.0% vs. 3.1 ± 1.9% in HC, p=0.04).
  • No significant differences in FMD or PWV were observed between groups.
  • Impaired retinal microvascular function was associated with longer SSc disease duration.

Conclusions:

  • Retinal microvascular function is significantly impaired in patients with SSc.
  • Retinal vessel analysis may serve as a valuable tool for risk assessment and prognosis in SSc, independent of cardiovascular risk factors.
  • The findings highlight the potential of retinal microcirculation assessment in managing SSc.