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The complex interplay between redox dysregulation and mTOR signaling pathway in cancer: A rationale for cancer

Christophe Glorieux1, Cinthya Enríquez2, Pedro Buc Calderon3

  • 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 510060 Guangzhou, China.

Biochemical Pharmacology
|December 21, 2024
PubMed

Insights

This review explores the mechanistic target of rapamycin (mTOR) pathway

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The mechanistic target of rapamycin (mTOR) is a key regulator of cell growth, proliferation, and metabolism.
  • Dysregulation of mTOR signaling and oxidative stress are linked to cancer development and progression.
  • Reactive oxygen species (ROS) have a complex, bidirectional relationship with mTOR signaling in cancer cells.

Purpose of the Study:

  • To provide a comprehensive overview of the mechanistic target of rapamycin (mTOR) pathway.
  • To elucidate the role of mTOR in cancer cell survival and metabolism.
  • To examine the intricate interplay between mTOR signaling and reactive oxygen species (ROS) in cancer.

Main Methods:

  • Literature review of current research on mTOR signaling in cancer.
  • Analysis of the mechanisms by which ROS influence mTOR activity.
  • Investigation of how mTOR signaling impacts oxidative stress and antioxidant gene expression in tumors.

Main Results:

  • ROS can either inhibit or activate the mTOR pathway in cancer cells via diverse mechanisms.
  • mTOR signaling can promote oxidative stress in tumor cells by suppressing antioxidant enzyme gene expression.
  • Activated mTOR is crucial for cancer cell survival, suggesting therapeutic potential for mTOR inhibitors.

Conclusions:

  • mTOR inhibitors, which often lead to ROS accumulation, represent a promising strategy for cancer therapy.
  • Understanding the complex interplay between mTOR and ROS is vital for optimizing cancer treatment.
  • Further research is needed to explore combination strategies and limitations of mTOR pathway modulation in cancer treatment.
Keywords:
CancerCell survivalMetabolismOxidative stressROSmTORmTOR inhibitors

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