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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Changing paradigms in asthma management.

Charles E Grogan1, Marlee Wadsworth1, Gailen D Marshall1

  • 1Division of Clinical Immunology, The University of Mississippi Medical Center, Jackson, MS, USA.

The American Journal of the Medical Sciences
|December 21, 2024
PubMed
Summary
This summary is machine-generated.

Advanced asthma therapies target specific inflammatory pathways, offering personalized treatments. However, high costs and variable patient responses necessitate exploring cost-effective alternatives and further research for optimal treatment selection.

Keywords:
AsthmaBiologicsCytokinesInflammation

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Area of Science:

  • Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Asthma is a chronic airway inflammatory disease with variable severity.
  • Current advanced treatments target specific inflammatory pathways like IgE, IL-5, IL-4 receptor, and TSLP.
  • These targeted therapies demonstrate efficacy in moderate to severe persistent asthma.

Purpose of the Study:

  • To review current advanced asthma therapies.
  • To address the significant financial burden of these treatments.
  • To explore alternative strategies and the need for personalized treatment selection.

Main Methods:

  • Review of current literature on asthma pathophysiology and treatment.
  • Analysis of approved and investigational biologic therapies.
  • Discussion of cost-effectiveness and patient response variability.

Main Results:

  • Several targeted therapies (anti-IgE, anti-IL-5, anti-IL-4Rα, anti-TSLP) are available for moderate to severe asthma.
  • High costs of biologic therapies present a burden to patients and healthcare systems.
  • Variability in patient response to current therapies is a significant clinical challenge.

Conclusions:

  • Novel therapies have advanced asthma management, but cost and response variability remain concerns.
  • Exploring novel uses of inhaled corticosteroids and long-acting bronchodilators may offer cost-effective alternatives.
  • Further research is crucial to identify biomarkers for predicting patient response to specific advanced asthma therapies.