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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...

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Related Experiment Video

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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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The collaborative working group method for pre-trial knowledge mobilisation: a qualitative evaluation of a structured

J P Breckenridge1, R Gossage-Worrall2, P Chadwick3

  • 1School of Health Sciences, University of Dundee, Dundee, UK.

Pilot and Feasibility Studies
|December 21, 2024
PubMed
Summary

This study introduces a Collaborative Working Group (CWG) to refine complex interventions before trials. The CWG proved acceptable and feasible, highlighting key elements for successful knowledge mobilization in research.

Keywords:
Co-designCollaborative workingFeasibility studyIntervention developmentKnowledge mobilisationPilot studyProcess evaluationQualitative researchType 1 diabetes

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Area of Science:

  • Health Services Research
  • Intervention Development
  • Knowledge Mobilization

Background:

  • Lack of practical guidance for knowledge mobilization at the pre-trial stage.
  • Existing guidance on complex interventions often theoretical, not practical.
  • Need for structured approaches to refine interventions before randomized controlled trials.

Purpose of the Study:

  • To evaluate the Collaborative Working Group (CWG) process for iterative refinement of complex interventions pre-trial.
  • To share practical lessons for knowledge mobilization in intervention development.
  • To provide guidance for future research teams.

Main Methods:

  • Embedded qualitative evaluation of the CWG process within the DAFNEplus research programme.
  • CWG involved monthly teleconferences and face-to-face meetings for knowledge sharing.
  • Data collected via focus groups, individual interviews, and documentary analysis.

Main Results:

  • Participants found the CWG acceptable, feasible, and useful for pre-trial intervention refinement.
  • Key success factors include knowledge funneling, trust negotiation, balancing practicalities, epistemic compromise, and managing power dynamics.
  • Adequate time and resources for trust-building and knowledge sharing are crucial.

Conclusions:

  • The CWG offers a practical approach to operationalizing collaborative intervention refinement pre-trial.
  • Provides tangible lessons and recommendations for research teams.
  • Adds practical guidance to intervention development and knowledge mobilization fields.