Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

25
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
25
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

194
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
194
Depression: Overview01:18

Depression: Overview

215
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
215
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

130
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
130
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

303
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
303

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental and quantitative observational research in fencing and wheelchair fencing: A scoping review.

PloS one·2026
Same author

A new self-management engagement scale for haemodialysis patients (PRIESM CKD-HD): development and validation.

Clinical kidney journal·2026
Same author

Effects of peppermint (Mentha x piperita L.) oil on cardiometabolic outcomes in patients with pre- and stage 1 hypertension: A placebo randomized controlled trial.

PloS one·2026
Same author

Who Should Decide the Outcome for a Clinical Trial? Comparing the Views of Stakeholders on Intervention Benefit Using Multi-Criteria Decision Modelling of Cognitive Remediation.

Schizophrenia bulletin·2026
Same author

At-risk registers integrated into primary care to stop asthma crises in the UK: cluster randomised controlled trial with economic evaluation.

Thorax·2026
Same author

Intervention Strategies for Healthcare Workers to Promote Vaccine Uptake in Ethnic Minority Populations: A Systematic Review of Behaviour Change Techniques.

Healthcare (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 4, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.4K

Energetic activity for depression in young people aged 13-17 years: the READY feasibility RCT.

Megan Smith1, Ryan James1,2, Neil Howlett2

  • 1Centre for Health Services and Clinical Research, University of Hertfordshire, Hatfield, UK.

Health Technology Assessment (Winchester, England)
|December 22, 2024
PubMed
Summary

This study found that while exercise interventions are acceptable for young people with depression, recruitment and retention pose significant challenges for large-scale trials. Future research needs improved strategies to overcome these barriers for effective intervention delivery.

Keywords:
BEHAVIOUR CHANGEDEPRESSIONEXERCISEFEASIBILITY RANDOMISED CONTROLLED TRIALLOW MOODPHYSICAL ACTIVITYYOUNG PEOPLE

More Related Videos

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.4K

Related Experiment Videos

Last Updated: Jun 4, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.4K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.4K

Area of Science:

  • Mental Health Research
  • Exercise Science
  • Public Health

Background:

  • Increasing prevalence of depression in young people necessitates novel interventions.
  • Exercise shows potential as a beneficial intervention for youth depression.
  • Robust trials are needed to confirm exercise effectiveness for young people with depression.

Purpose of the Study:

  • To assess the feasibility of an exercise intervention for young people with depression.
  • To evaluate recruitment and retention rates of young participants.
  • To examine the recruitment and training of exercise professionals and intervention delivery.

Main Methods:

  • A three-arm cluster feasibility randomized controlled trial.
  • Inclusion of process evaluation and health economic data collection.
  • Intervention involved high-intensity exercise, low-intensity exercise, or a social activity control for 12 weeks.

Main Results:

  • Recruitment challenges were significant, with 14 out of 81 target participants randomized.
  • Retention rate was 71.4%, with over 67% attendance at sessions.
  • The intervention was acceptable to young people, though barriers to delivery were identified.

Conclusions:

  • A large-scale randomized trial of this exercise intervention is not feasible with the current design due to recruitment issues.
  • Further work is required to address recruitment challenges for future studies.
  • Improved recruitment strategies are essential for the successful implementation of exercise interventions for youth depression.