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Physiological shedding and C-terminal proteolytic processing of TMEM106B

Sebastian Held1, Christian Erck2, Susanna Kemppainen3

  • 1Institute of Biochemistry, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24118 Kiel, Germany.

Cell Reports
|December 22, 2024
PubMed
Summary

Genetic variants in TMEM106B are linked to neurodegeneration. This study reveals lysosomal cysteine proteases generate and trim the TMEM106B luminal domain, a key step in understanding fibril formation in frontotemporal degeneration.

Keywords:
CP: Cell biologyCP: NeuroscienceFTLDSPPL2ATMEM106Bcathepsinsfibrilsluminal domainlysosomesproteolytic processingshedding

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