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Boldine reduces left ventricle oxidative stress in isoproterenol-induced adrenergic overload experimental model

Elissa Kerli Fernandes1, Patrick Türck1, Cristina Campos Carraro1

  • 1Laboratory of Cardiovascular Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

Archives of Physiology and Biochemistry
|December 22, 2024
PubMed

Insights

Boldine (BOL) protects the heart from damage caused by sustained adrenergic overload. BOL treatment reduced cardiac hypertrophy and oxidative stress, suggesting a therapeutic role in preventing adverse cardiac remodelling.

Area of Science:

  • Cardiology
  • Pharmacology
  • Oxidative Stress Research

Background:

  • Sustained adrenergic overload leads to maladaptive cardiac remodelling and oxidative stress.
  • Boldine (BOL), an antioxidant, presents a potential therapeutic strategy for cardiac conditions.

Purpose of the Study:

  • To investigate the cardioprotective effects of Boldine (BOL) against isoproterenol (ISO)-induced adverse left ventricular remodelling.
  • To evaluate BOL's impact on cardiac hypertrophy, diastolic dysfunction, and oxidative stress markers.

Main Methods:

  • Rats were divided into control, BOL, isoproterenol (ISO), and ISO + BOL groups.
  • Evaluated morphometric, echocardiographic, and oxidative stress parameters.
  • Assessed lipid peroxidation, superoxide dismutase (SOD), and glutathione-S-transferase (GST) levels.

Main Results:

  • BOL significantly attenuated cardiac hypertrophy and increased diastolic volume induced by ISO (P < 0.05).
  • BOL treatment reduced ISO-induced lipid peroxidation (P < 0.05).
  • BOL administration increased superoxide dismutase (SOD) and glutathione-S-transferase (GST) levels (P < 0.05).

Conclusions:

  • Boldine (BOL) demonstrates cardioprotective effects against isoproterenol-induced cardiac remodelling.
  • BOL may improve cardiac oxidative stress by enhancing antioxidant enzyme activity.
  • BOL shows promise as a therapeutic agent for conditions involving adrenergic overload and cardiac remodeling.

Keywords:
Antioxidantadrenergic agentscardiac hypertrophylipid peroxidationoxidative stress

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