Gliadin/Konjac glucomannan particle-stabilized Pickering emulsion for honokiol encapsulation with enhanced digestion...

Owing to the limited availability of biocompatible, edible and natural emulsifiers, the development of Pickering emulsions applicable to the food industry still confronts challenges. Moreover, Honokiol (HNK), due to its poor stability and susceptibility to oxidation, most of the existing delivery systems are centered on injection administration routes and relatively complex in preparation, posing significant challenges for industrialization. In this research, a Pickering emulsion system stabilized by gliadin and konjac glucomannan composite particles (GKPs) was constructed using the pH cycling method and was employed for the delivery of HNK. Under the conditions of a 1:2 mass ratio of the composite particles at pH 4 and an oil phase fraction of 50 %, the storage stability of HNK was effectively enhanced, attaining a retention rate of 84.88 % ± 0.78 % at 4 °C for 14 days. In simulated in vitro digestion, this emulsion system effectively mitigated the degradation of HNK, achieving a bioavailability of 66.94 % ± 4.05 % and increasing the release of free fatty acids. Pickering emulsions stabilized by GKPs may provide a useful means of delivery of bisphenol lignans.