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The relationship between HER2 status acquired from pathological data and metabolic parameters from pre-treatment [18F]FDG PET/CT in gastric adenocarcinomas

  • 0Department of Nuclear Medicine, University of Health Sciences, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Turkey.
Revista Espanola De Medicina Nuclear E Imagen Molecular +

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December 22, 2024

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December 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study found no link between Human Epidermal Growth Factor Receptor 2 (HER2) status and [18F]FDG PET/CT metabolic parameters in gastric cancer. However, PET/CT markers of tumor aggressiveness and prognosis were more predictive than HER2 status.

Area Of Science

  • Oncology
  • Nuclear Medicine
  • Radiomics

Background

  • Human Epidermal Growth Factor Receptor 2 (HER2) overexpression is linked to aggressive gastric cancer.
  • Assessing HER2 status and other prognostic factors is crucial for treatment planning and survival prediction.

Purpose Of The Study

  • To evaluate the predictive value of [18F]FDG PET/CT metabolic parameters for HER2 status in gastric cancer.
  • To investigate the association between PET/CT findings, pathological parameters, and patient survival.

Main Methods

  • Retrospective analysis of pretreatment [18F]FDG PET/CT metabolic parameters in 117 patients with known HER2 status.
  • Examination of relationships between pathological data, tumor metabolism, and distant metastases.
  • Investigation of the impact on overall survival using Cox-regression analysis.

Main Results

  • No significant association was found between [18F]FDG PET/CT parameters and HER2 status.
  • Vascular invasion, local invasion (T3/T4), and distant metastasis were identified as poor prognostic factors.
  • Distant metastasis correlated with higher SUVmax, SUVmean, and TLG, indicating increased tumor metabolism.

Conclusions

  • [18F]FDG PET/CT metabolic parameters do not correlate with HER2 expression in gastric cancer.
  • Tumor aggressiveness and prognosis are better predicted by PET/CT parameters than by HER2 status.
  • Distant metastasis, local invasion, and vascular invasion are associated with primary tumor metabolism, irrespective of HER2 status.

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