Related Experiment Video
Updated: Jun 4, 2025
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
Percutaneous coronary intervention (PCI) in patients of rheumatoid arthritis(RA): A systematic review and
Shobhit Piplani1, Anastas Kostojchin2, Steve Kong1
1Jacobi Medical Center/North Central Bronx, Albert Einstein College of Medicine, NYC Health and Hospitals, 3424 Kossuth Avenue, Bronx, NY, 10467, USA.
Insights
Percutaneous coronary intervention (PCI) in rheumatoid arthritis (RA) patients is linked to a higher risk of major adverse cardiovascular events. Careful monitoring and tailored care are crucial for these individuals undergoing PCI.
Area of Science:
- Cardiology
- Rheumatology
- Interventional Cardiology
Background:
- Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular risk.
- Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
Purpose of the Study:
- To investigate the outcomes of PCI in patients with RA.
- To compare cardiovascular event rates between RA patients and non-RA patients undergoing PCI.
Main Methods:
- A systematic literature search was performed across major databases up to September 2023.
- Eight observational studies were included in the meta-analysis.
- Statistical analyses were conducted using Review Manager 5.4.1 with a random-effect model.
Main Results:
- RA patients undergoing PCI showed a statistically significant increase in major adverse cardiovascular events (MACE) (OR = 1.18).
- No significant differences were observed in long-term revascularization outcomes between RA and non-RA patients.
- Long-term all-cause mortality rates were also statistically insignificant between the two groups.
Conclusions:
- PCI is vital for reducing morbidity and mortality in cardiovascular disease.
- Patients with RA undergoing PCI require heightened vigilance for medication interactions and tailored post-procedural care.
- Special precautions are essential to mitigate risks and improve outcomes for RA patients post-PCI.
Aim:
The present study aims to investigate the outcomes of Percutaneous coronary intervention (PCI) in patients with Rheumatoid arthritis (RA).
Methods:
A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 15th September 2023. All statistical analyses were conducted using Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result was reported in the odds ratio (OR) and the corresponding 95 % confidence interval (CI).
Results:
Eight observational studies were selected to conduct the analysis. A statistically significant increase in major adverse cardiovascular event (MACE) was seen in RA patients after undergoing PCI as compared to the control group (OR = 1.18 (1.16, 1.21); p < 0.00001; I2 = 0 %). There was no significant difference found in the long-term revascularization outcome between the RA and non-RA patients (OR = 1.18 (0.81, 1.71); p = 0.39; I2 = 93 %). Survival rates of all-cause mortality in the long-term outcome were statistically insignificant among the two groups (OR = 1.21 (0.84, 1.74); p = 0.31; I2 = 99 %).
Conclusion:
Percutaneous coronary intervention is an important intervention to reduce morbidity and mortality but special precautions and attention should be made when it comes to patients with RA. Different precautions such as close monitoring for medication interaction, and tailored post-procedural care are essential in reducing morbidity and mortality.
More Related Videos
06:31Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
11:03A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
Published on: October 30, 2019
Related Concept Videos
01:20The JAK-STAT Signaling Pathway
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
01:25Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...