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Dengue infection changes the expressions of CD154 and CD148 in human platelets

Sayali Vedpathak1, Sonali Palkar2, AkhileshChandra Mishra1

  • 1Department of Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune 411043, India.

Virus Research
|December 22, 2024
PubMed

Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. A significantly increased expression of CD154 and reduced expression of CD148 was observed in dengue patients compared to healthy subjects (p < 0.0001). Moreover, a strong positive correlation between CD148 and CD41/CD61 (p < 0.0001) was noted in dengue patients. In summary, we demonstrated the altered expressions of CD154 and CD148 on platelets in dengue patients that may play a crucial role in dengue pathogenesis.

Keywords:
CD148CD154CD41/CD61Dengue infectionPlatelets

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