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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery
Nicholas J Erickson1, Mihaela Stavarache2, Ibrahim Tekedereli1
1Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract:
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner.
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