[The advances of component resolved diagnosis in IgE-mediated cow's milk protein allergy]

Cow's milk protein allergy is the most common food allergy in infants and young children, and its prevalence has been increasing in recent years. The use of appropriate diagnostic methods is essential for the management of patients. Oral food challenges are not yet widely used in clinical practice, and new and more effective methods are still being sought, including component resolved diagnosis. Component resolved diagnosis has been introduced into the field of clinical allergy, which provides a new understanding for the diagnosis and treatment of allergic diseases. This article reviews the clinical application of component resolved diagnosis in IgE-mediated cow's milk protein allergy, especially the components of cow's milk protein allergy and the identification of co-sensitization, the research progress of diagnosis, the prediction of the development of tolerance and the risk of allergic reactions, the guidance of allergen immunotherapy and the development of personalized diet for patients, in order to provide a basis for the diagnosis, treatment and prevention of IgE-mediated cow's milk protein allergy.