Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
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View abstract on PubMed
Summary
This summary is machine-generated.Short sleep duration disrupts the body's energy balance by affecting the suprachiasmatic nucleus (SCN) and its regulation of feeding behaviors, potentially leading to obesity.
Area Of Science
- Neuroscience
- Metabolism
- Chronobiology
Background
- Short sleep duration is linked to increased energy intake and obesity risk.
- The suprachiasmatic nucleus (SCN) regulates circadian rhythms, including feeding and energy metabolism, via projections to the arcuate nucleus (ARC) and paraventricular nucleus (PVN).
Purpose Of The Study
- To elucidate the causal mechanisms linking short sleep duration to altered energy balance and obesity risk.
Main Methods
- Investigated the effects of chronic sleep deprivation (SD) on gene expression in the SCN.
- Utilized adeno-associated virus (AAV)-mediated genetic overexpression of BMAL1 in the SCN of mice.
- Examined neuronal projections and energy expenditure.
Main Results
- Chronic SD led to aberrant expression of AgRP/NPY and POMC due to compromised JAK/STAT3 signaling and reduced energy expenditure.
- Overexpression of BMAL1 in the SCN rescued these effects.
- Disruptions in SCN efferent pathways mediated by BMAL1 were implicated.
Conclusions
- Chronic SD impairs energy balance by reducing BMAL1 expression in the SCN, affecting neuronal projections to the ARC and PVN.
- This provides a potential causal link between sleep curtailment and obesity, particularly in adolescents.
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