Related Experiment Video
Updated: Jun 1, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Intracranial Castleman's Disease Mimicking Dural-based Pathologies: A Case Report
Ambar Elizabeth Riley Moguel1, Alejandro Serrano-Rubio1, Jose Alfredo Gonzalez Soto1
1Department of Vascular Neurosurgery, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", 14267, Mexico City, Mexico.
Background:
Castleman disease (CD) is a rare lymphoproliferative disorder, with intracranial involvement being exceedingly rare. Unicentric Castleman disease (UCD) is typically benign and localized, but its presentation can mimic other intracranial pathologies, complicating diagnosis.
Case Description:
We reported a 52-year-old woman who presented with progressive headaches and language disturbances. Imaging, including MRI and CT, revealed an extra-axial left frontotemporal lesion initially diagnosed as an en plaque meningioma. Surgical resection of the lesion was performed. Histopathological examination revealed UCD with plasma cell predominance, characterized by lymphoid hyperplasia and concentric germinal centers. Immunohistochemical staining confirmed the diagnosis, with positive markers including CD20, CD3, and CD16.
Conclusion:
Intracranial UCD is a rare and challenging differential diagnosis for extra-axial lesions, often resembling meningiomas. Accurate diagnosis requires a combination of imaging and histopathology, with immunohistochemistry playing a crucial role. Complete surgical resection is the optimal treatment for localized UCD.
