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Intracranial Castleman's Disease Mimicking Dural-based Pathologies: A Case Report
Ambar Elizabeth Riley Moguel1, Alejandro Serrano-Rubio1, Jose Alfredo Gonzalez Soto1
1Department of Vascular Neurosurgery, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", 14267, Mexico City, Mexico.
Current Medical Imaging
|December 23, 2024
Summary
Unicentric Castleman disease (UCD) is a rare cause of intracranial lesions that can mimic meningiomas. Early diagnosis via imaging and histopathology is crucial for effective treatment.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Castleman disease (CD) is a rare lymphoproliferative disorder.
- Intracranial involvement is exceptionally rare, with unicentric Castleman disease (UCD) often presenting benignly but mimicking other pathologies.
Observation:
- A 52-year-old woman presented with headaches and language disturbances.
- Imaging revealed an extra-axial lesion misdiagnosed as meningioma.
- Histopathology and immunohistochemistry confirmed UCD with plasma cell predominance.
Findings:
- UCD can present as an intracranial extra-axial lesion.
- Diagnosis requires integrated imaging and histopathological analysis.
- Immunohistochemistry is vital for confirming UCD.
Implications:
- Intracranial UCD is a rare differential diagnosis for extra-axial lesions.
- Accurate diagnosis relies on comprehensive histopathology and imaging.
- Complete surgical resection is the standard treatment for localized UCD.
Keywords:
Hyaline vascular typeIntracranial castleman diseaseLymphoproliferative diseasePlaque meningiomaPlasma cell typeUnicentric Castleman Disease.
