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Invasive bladder cancer treated by radical external radiotherapy
British Journal of Urology
|February 1, 1985
Summary
Radical radiotherapy shows effectiveness for invasive bladder cancer (Stage T2-T3). Further research is needed to identify tumors that do not respond well to this treatment early on.
Area of Science:
- Oncology
- Radiotherapy
- Urologic Oncology
Background:
- Invasive bladder cancer (Stage T2-T3) requires effective treatment strategies.
- Radical radiotherapy is a primary treatment modality for these patients.
Purpose of the Study:
- To review outcomes of radical radiotherapy for invasive bladder cancer (Stage T2-T3).
- To evaluate the role of cystectomy in patients treated with radiotherapy.
- To assess the 5-year survival rate following radical radiotherapy.
Main Methods:
- Retrospective review of 53 consecutive patients with invasive bladder cancer (Stage T2-T3).
- Patients were treated with radical radiotherapy.
- Cystectomy was reserved for specific clinical indications like disease progression or persistent symptoms.
Main Results:
- A favorable tumor response to radiotherapy was observed in 64% of patients.
- Disease progression occurred during or after radiotherapy in 31% of patients.
- Cystectomy was performed in 22% of patients, primarily for radiation cystitis, with no significant operative mortality.
Conclusions:
- Radical radiotherapy is an effective treatment for invasive bladder cancer, comparable to other modalities.
- There is a need to identify bladder tumors with poor radiotherapy response earlier.
- Further investigation into predictive markers for radiotherapy response is warranted.
