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Targeting long noncoding RNA H19 in subchondral bone osteocytes and cartilage degradation in osteoarthritis: comment

An-Fang Huang1, Wang-Dong Xu2

  • 1Affiliated Hospital of Southwest Medical University, Sichuan, China.

Arthritis & Rheumatology (Hoboken, N.J.)
|December 23, 2024
PubMed
Abstract

No abstract available in PubMed .

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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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