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Updated: Jun 4, 2025

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
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Schwann Cell-Secreted S100B Promotes Wound Healing via Paracrine Modulation.

Y Zhou1, K Li2, Z Ma1

  • 1Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Journal of Dental Research
|December 23, 2024
PubMed
Summary

Schwann cells are crucial for palatal mucosa wound healing, secreting S100B protein that accelerates tissue repair via a specific signaling pathway. This discovery offers new therapeutic insights for wound healing treatments.

Keywords:
Receptor for Advanced Glycation End Products (RAGE)S100beta Proteinglial cellsmultiomicspalatal mucosawounds

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Tissue Engineering

Background:

  • Palatal tissue exhibits significant regenerative capacity, essential for gingival grafts, but the underlying mechanisms remain unclear.
  • Schwann cells are known to participate in wound repair across various tissues, suggesting a potential role in mucosal healing.

Purpose of the Study:

  • To investigate the role of Schwann cells in the wound healing process of palatal mucosa.
  • To elucidate the specific molecular mechanisms by which Schwann cells contribute to palatal wound regeneration.

Main Methods:

  • Multiomics analysis (scRNA-seq and proteomics) in nonhuman primates.
  • Development of wound-healing models in palatal mucosa, buccal attached gingiva, and skin.
  • In vivo validation using GelMA hydrogels in rat and monkey skin models.

Main Results:

  • Palatal mucosa shows higher distribution and lower differentiation of Schwann cells at baseline compared to other tissues.
  • Elevated S100B levels were observed during palatal wound healing.
  • Schwann cell-secreted S100B promotes fibroblast activity via the S100B/RAGE axis, activating NF-κB and Notch signaling for faster wound closure.

Conclusions:

  • Schwann cells play a vital role in palatal mucosa wound healing through the S100B/RAGE/NF-κB/Notch paracrine signaling axis.
  • S100B protein demonstrates therapeutic potential for enhancing wound healing.
  • This study provides novel insights into the regenerative capabilities of palatal tissue and identifies key cellular players and pathways involved.