Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: MRS4Brain: a software for preclinical proton and deuterium-based MR spectroscopic imaging data.

Magma (New York, N.Y.)·2026
Same author

High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Correcting motion-related B<sub>0</sub> inhomogeneities in magnetic resonance imaging via combined spherical harmonics and AC/DC matrix coils using DL-based prediction-simulation study.

Scientific reports·2026
Same author

Transformer networks enable fast and robust dictionary generation for multiparametric cardiac mapping with variable timing.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026
Same author

Metabolic modelling and time-resolved mapping of glucose oxidative metabolism in the rat brain by indirect deuterium detection with <sup>1</sup>H-FID-MRSI at 9.4 T.

Magma (New York, N.Y.)·2026
Same author

Click Chemistry Functionalization of Harmonic Nanoparticles with Lanthanide Complexes Towards Tunable Platforms for Multimodal Imaging.

Nanomaterials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 4, 2025

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts
09:01

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts

Published on: September 21, 2014

14.7K

Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T.

Dunja Simicic1,2, Brayan Alves1,2, Jessie Mosso1,2,3

  • 1CIBM Center for Biomedical Imaging, Lausanne, Switzerland.

NMR in Biomedicine
|December 23, 2024
PubMed
Summary

This study introduces a new method for high-resolution proton magnetic resonance spectroscopic imaging (¹H-MRSI) in rat brains at ultra-high magnetic fields. The technique offers robust, reproducible metabolic mapping with improved signal-to-noise ratio and spatial resolution.

Keywords:
1H‐FID‐MRSIbrain metabolitesmagnetic resonance spectroscopic imagingmetabolite mappingrat brainultra‐high field

More Related Videos

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation
09:26

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Published on: February 8, 2019

8.6K
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
07:28

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

240

Related Experiment Videos

Last Updated: Jun 4, 2025

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts
09:01

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts

Published on: September 21, 2014

14.7K
Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation
09:26

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Published on: February 8, 2019

8.6K
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
07:28

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

240

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Spectroscopy
  • Preclinical Research

Background:

  • Proton magnetic resonance spectroscopic imaging (¹H-MRSI) is valuable for noninvasive brain analysis.
  • Preclinical application of ¹H-MRSI is limited by low signal-to-noise ratio (SNR) and small voxel sizes in rodent models.
  • Ultra-high magnetic fields offer potential for improved SNR and resolution in preclinical MRSI.

Purpose of the Study:

  • To implement and validate a free induction decay ¹H-MRSI (¹H-FID-MRSI) sequence at 14.1 Tesla for rat brain analysis.
  • To develop a dedicated processing pipeline (MRS4Brain) for enhanced data analysis.
  • To achieve high spatial resolution and reproducible metabolic mapping in the preclinical setting.

Main Methods:

  • Utilized a ¹H-FID-MRSI sequence at 14.1 Tesla in rat brains.
  • Developed a custom processing pipeline with a graphical user interface (MRS4Brain toolbox).
  • Employed LCModel fitting with simulated and in vivo metabolite basis sets for spectral analysis.

Main Results:

  • Achieved high signal-to-noise ratio (SNR) and spectral resolution, enabling high spatial resolution.
  • Demonstrated reliable quantification of eight key brain metabolites with low Cramér-Rao lower bounds (<30%).
  • Produced highly reproducible metabolic maps, confirming known regional metabolite distributions, with minimal technical limitations.

Conclusions:

  • High-resolution ¹H-FID-MRSI at 14.1 Tesla is feasible and effective for preclinical rat brain metabolic mapping.
  • The developed sequence and processing pipeline provide robust, reproducible, and high-quality results.
  • This technique overcomes previous limitations, paving the way for advanced preclinical neuroscience research.