Related Experiment Video

Updated: Jun 4, 2025

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
11:00

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

938

RNA-binding protein quaking: a multifunctional regulator in tumour progression

Wangyu Zhu1,2, Weiwei Yang1,2, Guoping Sun3

  • 1Cell and Molecular Biology Laboratory, Zhoushan Hospital of Wenzhou Medical University, Zhoushan, Zhejiang, China.

Annals of Medicine
|December 23, 2024
PubMed
Abstract

Insights

Quaking (QKI) regulates RNA processing and impacts tumor progression, acting as both an oncogene and tumor suppressor. Further research is needed to fully understand its complex role in cancer development and treatment.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • RNA Biology

Background:

  • Quaking (QKI), a STAR family member, is vital for RNA processing, including splicing, transport, and translation.
  • Aberrant QKI expression or mutations contribute to tumor progression by altering RNA and protein expression.
  • QKI's role in cancer is complex, functioning as both an oncogene and a tumor suppressor depending on the tumor type.

Purpose of the Study:

  • To review QKI isoforms and functions in tumor progression.
  • To analyze the impact of QKI-regulated gene expression on cancer.
  • To explore QKI's potential as a predictive marker and therapeutic target in oncology.

Main Methods:

  • Systematic review of recent scientific literature.
  • Summarization of QKI's functional alterations in tumor progression.

Main Results:

  • QKI regulates post-transcriptional gene expression, affecting alternative splicing, polyadenylation, mRNA stability, and localization.
  • QKI dysregulation correlates with tumor proliferation, metastasis, angiogenesis, stem cells, microenvironment, and treatment sensitivity.
  • QKI alterations serve as potential biomarkers for tumor diagnosis and prognosis.

Conclusions:

  • QKI acts as a critical tumor suppressor or oncogene in tumor progression, influenced by splicing variations and tumor microenvironment.
  • Understanding QKI's diverse roles requires ongoing research into its mechanisms and functions in cancer regulation.
Keywords:
QKIpost-translational regulationtumour progression

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

6.7K
In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

10.6K

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.8K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
869
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.1K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K