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Updated: Jun 4, 2025
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Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
Published on: June 23, 2023
938
RNA-binding protein quaking: a multifunctional regulator in tumour progression
Wangyu Zhu1,2, Weiwei Yang1,2, Guoping Sun3
1Cell and Molecular Biology Laboratory, Zhoushan Hospital of Wenzhou Medical University, Zhoushan, Zhejiang, China.
Annals of Medicine
|December 23, 2024
Summary
Quaking (QKI) regulates RNA processing and impacts tumor progression, acting as both an oncogene and tumor suppressor. Further research is needed to fully understand its complex role in cancer development and treatment.
Area of Science:
- Molecular Biology
- Cancer Research
- RNA Biology
Background:
- Quaking (QKI), a STAR family member, is vital for RNA processing, including splicing, transport, and translation.
- Aberrant QKI expression or mutations contribute to tumor progression by altering RNA and protein expression.
- QKI's role in cancer is complex, functioning as both an oncogene and a tumor suppressor depending on the tumor type.
Purpose of the Study:
- To review QKI isoforms and functions in tumor progression.
- To analyze the impact of QKI-regulated gene expression on cancer.
- To explore QKI's potential as a predictive marker and therapeutic target in oncology.
Main Methods:
- Systematic review of recent scientific literature.
- Summarization of QKI's functional alterations in tumor progression.
Main Results:
- QKI regulates post-transcriptional gene expression, affecting alternative splicing, polyadenylation, mRNA stability, and localization.
- QKI dysregulation correlates with tumor proliferation, metastasis, angiogenesis, stem cells, microenvironment, and treatment sensitivity.
- QKI alterations serve as potential biomarkers for tumor diagnosis and prognosis.
Conclusions:
- QKI acts as a critical tumor suppressor or oncogene in tumor progression, influenced by splicing variations and tumor microenvironment.
- Understanding QKI's diverse roles requires ongoing research into its mechanisms and functions in cancer regulation.
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