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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Treatment Resistent Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jul 6, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Update on Conventional Osteosarcoma.

Luiz Eduardo Moreira Teixeira1, Alex Guedes2, Suely Akiko Nakagawa3

  • 1Departamento do Aparelho Locomotor, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Revista Brasileira De Ortopedia
|December 23, 2024
PubMed
Summary
This summary is machine-generated.

High-grade osteosarcoma, a bone cancer in children and adolescents, is treated with chemotherapy and surgery. Advances improve survival and limb preservation rates for this malignant tumor.

Keywords:
neoplasmsostesarcomasarcoma

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Area of Science:

  • Orthopedics
  • Pediatric Oncology
  • Surgical Oncology

Background:

  • Conventional osteosarcoma is a high-grade malignant bone tumor.
  • It is characterized by osteoid matrix production by malignant osteoblasts.
  • Typically affects long bones in children and adolescents.

Purpose of the Study:

  • To review the current status of conventional high-grade osteosarcoma.
  • To discuss incidence, pathology, treatment, and prognosis.
  • To highlight recent advances impacting survival and limb preservation.

Main Methods:

  • Literature review of current oncology concepts.
  • Analysis of advancements in imaging and surgical planning.
  • Examination of updated cancer treatment protocols.

Main Results:

  • Improved survival rates in osteosarcoma patients.
  • Higher limb preservation rates achieved through modern treatment.
  • Current treatment involves systemic chemotherapy and wide surgical resection.

Conclusions:

  • Conventional high-grade osteosarcoma remains a significant challenge.
  • Advances in multimodal treatment offer improved outcomes.
  • Ongoing research continues to refine treatment strategies and prognosis.