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Related Concept Videos

Immunological Memory01:23

Immunological Memory

527
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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  9. Agricultural Biotechnology Diagnostics (incl. Biosensors)
  11. Assessment Of Immunological Response To Digital Dermatitis Pathogen Derived Antigens Following Infection, Recovery, And Reinfection

Assessment of immunological response to digital dermatitis pathogen derived antigens following infection, recovery, and reinfection

John W Coatney1, Adam C Krull1, Patrick J Gorden1

  • 1College of Veterinary Medicine, Iowa State University, Ames, IA, United States.

Frontiers in Veterinary Science
|December 23, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Immunity after bovine digital dermatitis (bovine DD) infection offers only partial protection against reinfection. Further research is needed to understand the immune mechanisms behind this partial resistance in dairy calves.

Area of Science:

  • Veterinary Immunology
  • Bovine Infectious Diseases
  • Lameness in Cattle

Background:

  • Bovine digital dermatitis (DD) is a significant cause of lameness in dairy cattle.
  • Understanding immune responses to DD is crucial for developing effective control strategies.
  • Previous infection and lesion resolution may confer some level of protection against subsequent DD challenges.

Purpose of the Study:

  • To evaluate the immune response and lesion development in dairy calves after primary and secondary experimental infections with bovine digital dermatitis (DD).
  • To compare the humoral and cell-mediated responses between newly infected calves, previously infected and re-infected calves, and naive calves.
  • To assess the protective effect of prior DD infection against subsequent experimental re-infection.

Main Methods:

Keywords:
animal modelbovinedigital dermatitisgamma-delta T-cell

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  • Experimental induction of bovine digital dermatitis (DD) in two groups of dairy calves: naive and previously infected.
  • Assessment of humoral (serum antibody titers) and cell-mediated (lymphocyte proliferation) immune responses.
  • Clinical scoring of lesions by a blinded observer using a standardized scoring system.
  • Comparison of lesion development and immune responses between the two groups.

Main Results:

  • All naive calves developed lesions after initial infection, while only 5 of 8 previously infected calves developed lesions upon re-infection.
  • Lesions consistent with DD occurred in 15/26 experimentally infected feet in the naive group and 10/25 in the re-infected group.
  • No significant differences in humoral or cellular immune responses were observed between the groups or between calves that developed lesions and those that did not.

Conclusions:

  • Resolution of bovine digital dermatitis (DD) lesions confers only partial immunity against subsequent experimental re-infection.
  • Immune mechanisms providing partial protection against DD reinfection require further investigation.
  • The study highlights the complexity of immune responses to DD and the need for continued research into protective immunity.
immune response
lameness