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Related Concept Videos

General Anesthesia: Overview01:24

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Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
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Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
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Related Experiment Video

Updated: Jun 4, 2025

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The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke

Yangning Zhou1, Yan Wang2, Limin Xu1

  • 1Department of Anesthesiology, Shanghai United Family Hospital, Shanghai 200050, China.

Open Medicine (Warsaw, Poland)
|December 23, 2024
PubMed
Summary

This study developed a predictive model for postoperative cognitive dysfunction (POCD) after acute ischemic stroke (AIS) using inflammatory and brain injury markers. The model effectively predicts POCD and suggests anesthesia depth may influence cognitive outcomes.

Keywords:
acute ischemic strokeanesthesia depthcognitive impairmentnomogramprediction

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Area of Science:

  • Neuroscience
  • Cardiology
  • Critical Care Medicine

Background:

  • Postoperative cognitive dysfunction (POCD) is a common complication following endovascular therapy for acute ischemic stroke (AIS).
  • Predicting AIS and its complications remains clinically complex, necessitating proactive models.
  • The influence of anesthesia depth on cognitive outcomes in AIS patients requires further investigation.

Purpose of the Study:

  • To develop and validate a predictive model for POCD in AIS patients.
  • To identify key clinical and biochemical indicators associated with POCD.
  • To explore the relationship between anesthesia depth and cognitive impairment in AIS.

Main Methods:

  • A cohort of 333 AIS patients (232 non-POCD, 101 POCD) was analyzed.
  • Univariate and multivariate logistic regression identified independent risk factors for POCD.
  • A nomogram model was constructed using identified indicators and validated with calibration and precision-recall curves.

Main Results:

  • Key predictors for POCD included inflammatory markers (hs-CRP, SII) and brain injury indicators (NIHSS, NT-proBNP, S100-β).
  • The composite nomogram model demonstrated predictive efficacy for POCD post-AIS.
  • A potential association between anesthesia depth, cognitive impairment, and inflammation was observed.

Conclusions:

  • A nomogram integrating NIHSS, hs-CRP, SII, NT-proBNP, and S100-β effectively predicts POCD in AIS patients.
  • Anesthesia depth may play a role in cognitive outcomes and inflammatory responses in AIS.
  • This model aids in preemptive risk assessment and management of POCD in AIS.