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Mechanism of the Mitsunobu Reaction: An Ongoing Mystery
Elizabeth A Croll1, Ohyun Kwon1
1Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Synthesis
|December 23, 2024
Abstract:
The Mitsunobu reaction is one the most widely known reactions in the organic chemistry canon. Despite its fame, some aspects of the mechanism remain poorly understood, 55 years after its initial discovery. This short review collates the findings of several publications focused on the mechanism of the Mitsunobu reaction, highlighting both the current state of knowledge and the remaining missing pieces.
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