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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Related Experiment Video

Updated: Jun 4, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Bullous Pemphigoid Onset Following Vaccination in Infancy: A Case Report.

Sondos Hassanin1, Arnav Katira1, Nicola Hardcastle1

  • 1Dermatology, Sheffield Children's Hospital, Sheffield, GBR.

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|December 23, 2024
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Summary
This summary is machine-generated.

Bullous pemphigoid, an autoimmune blistering disease, may be linked to vaccinations. A case study shows an infant developed bullous pemphigoid after routine immunisation, responding well to treatment.

Keywords:
autoimmune blistering diseasebullous pemphigoidinfancyvaccinationvaccine adverse events

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Area of Science:

  • Dermatology
  • Immunology
  • Pediatrics

Background:

  • Bullous pemphigoid (BP) is a rare autoimmune blistering disease.
  • It is characterized by autoantibodies targeting basal skin membrane antigens.
  • The exact etiology of BP remains unclear, but recent cases suggest a potential link with immunisation.

Observation:

  • This study presents a case of bullous pemphigoid onset in a four-month-old infant.
  • The infant developed the condition following routine vaccination.

Findings:

  • The infant diagnosed with bullous pemphigoid responded well to systemic therapy.
  • This case highlights a potential association between bullous pemphigoid and vaccination.

Implications:

  • Further research is needed to investigate the potential link between bullous pemphigoid and vaccination.
  • This case underscores the importance of monitoring for autoimmune conditions post-immunisation.