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Updated: Jun 4, 2025

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Synthesis, crystal structure and absolute configuration of
Alejandro Peixoto de Abreu Lima1, Enrique Pandolfi1, Valeria Schapiro1
1Laboratorio de Síntesis Orgánica Departamento de Química Orgánica Facultad de Química Universida de la República Avenida General Flores 2124 CP 11800 Montevideo Uruguay.
Abstract:
The absolute configuration of the title compound, C13H16O4, determined as 1S,2R,3S,4R based on the synthetic pathway, was confirmed by single-crystal X-ray diffraction. The mol-ecule is a relevant inter-mediary for the synthesis of speciosins, ep-oxy-quinoides or their analogues. The mol-ecule contains fused five- and six-membered rings with two free hydroxyl groups and two protected as an iso-propyl-idenedioxo ring. The packing is directed by hydrogen bonds that define double planes of mol-ecules laying along the ab plane and van der Waals inter-actions between aliphatic chains that point outwards of the planes.
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