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Published on: April 11, 2016
Advances and prospects of precision nanomedicine in personalized tumor theranostics
Yuhang Mao1,2,3, Juanping Xie1,3, Fang Yang4
1School of Medicine, Ankang University, Ankang, China.
Abstract:
Tumor, as the second leading cause of death globally, following closely behind cardiovascular diseases, remains a significant health challenge worldwide. Despite the existence of various cancer treatment methods, their efficacy is still suboptimal, necessitating the development of safer and more efficient treatment strategies. Additionally, the advancement of personalized therapy offers further possibilities in cancer treatment. Nanomedicine, as a promising interdisciplinary field, has shown tremendous potential and prospects in the diagnosis and treatment of cancer. As an emerging approach in oncology, the application of nanomedicine in personalized cancer therapy primarily focuses on targeted drug delivery systems such as passive targeting drug delivery, active targeting drug delivery, and environmentally responsive targeting drug delivery, as well as imaging diagnostics such as tumor biomarker detection, tumor cell detection, and in vivo imaging. However, it still faces challenges regarding safety, biocompatibility, and other issues. This review aims to explore the advances in the use of nanomaterials in the field of personalized cancer diagnosis and treatment and to investigate the prospects and challenges of developing personalized therapies in cancer care, providing direction for the clinical translation and application.
Insights
Nanomedicine offers promising personalized cancer diagnosis and treatment strategies, focusing on targeted drug delivery and advanced imaging. Further research is needed to address safety and biocompatibility for clinical translation.
Area of Science:
- Oncology
- Nanomedicine
- Biotechnology
Background:
- Cancer is a leading global cause of death, with current treatments showing suboptimal efficacy.
- Personalized therapy presents new avenues for cancer treatment.
- Nanomedicine is an emerging interdisciplinary field with significant potential in oncology.
Purpose of the Study:
- To review advances in nanomaterial applications for personalized cancer diagnosis and treatment.
- To explore the prospects and challenges of nanomedicine in personalized cancer therapy.
- To provide direction for the clinical translation of nanomedicine in cancer care.
Main Methods:
- Review of nanomedicine applications in targeted drug delivery (passive, active, environmentally responsive).
- Examination of nanomedicine in imaging diagnostics (biomarker detection, cell detection, in vivo imaging).
- Analysis of challenges including safety and biocompatibility.
Main Results:
- Nanomedicine enables targeted drug delivery systems for personalized cancer therapy.
- Nanomaterials enhance diagnostic capabilities through advanced imaging techniques.
- Current nanomedicine approaches face challenges in safety and biocompatibility.
Conclusions:
- Nanomedicine holds substantial promise for personalized cancer diagnosis and treatment.
- Addressing safety and biocompatibility is crucial for clinical translation.
- Further research is essential to optimize nanomedicine strategies for effective cancer care.
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