Related Experiment Video
Updated: Jun 4, 2025
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.5K
Bullous Pemphigoid Induced by Cefixime: A Rare Side Effect.
Nicolas Sandakly1, Georgio El Koubayati2, Hussein Nassereddine3
1Internal Medicine, Lebanese University Faculty of Medicine, Beirut, LBN.
Cureus
|December 23, 2024
Summary
Bullous pemphigoid (BP), a blistering skin disease, can be triggered by medications. This case highlights cefixime as a potential cause, emphasizing the need for medical review in elderly patients with new skin eruptions.
Area of Science:
- Dermatology
- Autoimmune Blistering Diseases
Background:
- Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease, primarily affecting the elderly.
- BP presents with itchy, blistering skin lesions and has been linked to certain medications like DPP4 inhibitors and antibiotics.
Observation:
- An 85-year-old female developed widespread vesicles and bullae after a course of cefixime for pyelonephritis.
- Diagnosis was confirmed as bullous pemphigoid via clinical examination and histopathology.
Findings:
- This report documents the first case of bullous pemphigoid (BP) induced by the antibiotic cefixime.
- The patient's BP responded effectively to corticosteroid treatment.
Implications:
- Highlights cefixime as a potential drug-induced cause of bullous pemphigoid.
- Stresses the importance of considering medication history in elderly patients presenting with blistering skin conditions.
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