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Published on: September 27, 2024
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Dynamic microbial changes in exacerbation of chronic obstructive pulmonary disease
Yong Jun Choi1, Hye Jung Park1, Chi Young Kim1
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Frontiers in Microbiology
|December 23, 2024
Summary
Chronic obstructive pulmonary disease (COPD) exacerbations are linked to altered microbial diversity. Maintaining a balanced respiratory microbiome is crucial for preventing and managing COPD exacerbations.
Area of Science:
- Microbiology
- Pulmonary Medicine
- Genomics
Background:
- Microbial profiles in patients with chronic obstructive pulmonary disease (COPD) offer insights into predicting, preventing, and treating exacerbations.
- Understanding the respiratory microbiome's role in COPD exacerbations is vital for clinical management.
Purpose of the Study:
- To analyze the impact of microbial diversity and spectrum on COPD exacerbations.
- To investigate differences in microbial composition between stable COPD and exacerbation states.
Main Methods:
- Prospective enrollment of patients with stable COPD and COPD exacerbation (ECOPD) from November 2018 to May 2023.
- Sputum sample collection for microbiome DNA sequencing and amplicon sequence variant analysis.
- Comparison of microbial diversity indices and genus/species abundance between stable and exacerbation phases.
Main Results:
- Significantly higher alpha diversity (observed features, Fisher's alpha) in stable COPD compared to the exacerbation phase (AE-1).
- Increased abundance of genera including Neisseria, Fusobacterium, and Peptostreptococcus, and species N. perflava and H. parainfluenzae in stable COPD.
- Distinct microbial network hub genera identified between stable COPD (Haemophilus, Neisseria, Lactobacillus) and exacerbation phases (Streptococcus, Klebsiella, Staphylococcus).
Conclusions:
- COPD exacerbations are associated with specific alterations in the normal respiratory flora.
- Maintaining microbial diversity and a balanced microbial network is critical for COPD exacerbation prevention and management.
Keywords:
chronic obstructive pulmonary diseasedisease mechanismsexacerbationsmicrobial diversitymicrobiomerespiratory healthMore Related Videos
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