Phosphopeptide Neoantigens as Emerging Targets in Cancer Immunotherapy
Tyagi Apoorvi1,2, Patskovsky Yury1,2, Voloshyna Iryna1,2
1Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
Journal of Cancer Immunology
|December 23, 2024
Summary
Phosphorylated peptides (p-peptides) are novel tumor-specific antigens. Aberrant protein phosphorylation in cancer generates these peptides, offering new targets for cancer immunotherapy.
Area of Science:
- Biochemistry
- Immunology
- Oncology
Background:
- Protein post-translational modifications are crucial for cellular functions.
- Aberrant modifications in cancer cells create tumor-specific antigens.
- Phosphorylated peptides (p-peptides) are a focus for cancer immunity.
Purpose of the Study:
- To review the role of p-peptides in cancer immunity.
- To discuss how phosphorylation affects peptide-MHC interactions.
- To explore p-peptide interactions with T-cell receptors (TCRs).
Main Methods:
- Literature review of studies on p-peptides in cancer.
- Analysis of structural and binding properties of p-peptides.
- Examination of TCR interactions with specific p-peptides.
Main Results:
- Phosphorylation alters peptide structure and MHC binding.
- p-peptides represent a distinct class of tumor antigens.
- Specific p-peptides show interactions with TCRs, like HLA-B*07-specific pMLL747-755.
Conclusions:
- p-peptides are emerging as valuable targets in cancer immunotherapy.
- Understanding p-peptide recognition expands therapeutic strategies.
- These modified peptides broaden the scope of tumor-specific antigens.
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