Ferroptosis and its impact on common diseases

Area of Science:

• Biomedical Science
• Cell Biology
• Pathophysiology

Background:

• Ferroptosis is a regulated cell death pathway involving iron accumulation and lipid peroxidation.
• This cell death mechanism is implicated in the pathogenesis of numerous common diseases.
• Understanding ferroptosis is crucial for developing novel therapeutic strategies.

Purpose of the Study:

• To explore the theoretical basis and mechanisms of ferroptosis.
• To review the role of ferroptosis in various common diseases.
• To discuss the therapeutic prospects and clinical translation of targeting ferroptosis.

Main Methods:

• Literature review and theoretical analysis.
• Exploration of gene expression regulation in ferroptosis.
• Synthesis of current research on ferroptosis in disease.

Main Results:

• Ferroptosis is linked to ischemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer's disease, cardiovascular disease, immune disorders, and cancer.
• Gene expression plays a regulatory role in ferroptosis.
• Significant research is ongoing regarding ferroptosis's therapeutic potential.

Conclusions:

• Ferroptosis is a key factor in the development of common diseases.
• Targeting ferroptosis offers promising therapeutic avenues.
• This review provides a foundation for future ferroptosis research and clinical applications.