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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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Advances in addressing antimicrobial resistance.

C A Carson, J S Weese

    Revue Scientifique Et Technique (International Office of Epizootics)
    |December 23, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Antimicrobial resistance (AMR) is a growing global threat affecting animals and humans. This article reviews advances in combating AMR in animals through surveillance, stewardship, and new treatments.

    Keywords:
    Antimicrobial resistanceAntimicrobial stewardshipAntimicrobial useSurveillanceVeterinary

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    Area of Science:

    • Veterinary Medicine
    • Microbiology
    • Public Health

    Background:

    • Antimicrobial resistance (AMR) is a silent pandemic with significant impacts on animal health, welfare, production, food safety, and the economy.
    • AMR is a One Health issue, affecting humans, animals, plants, and the environment in complex, interconnected ways.

    Purpose of the Study:

    • To describe recent advances in addressing AMR in bacteria from animals.
    • To highlight progress in surveillance, stewardship, drug development, and alternatives to antimicrobials.

    Main Methods:

    • Review of recent advances in combating AMR in animal populations.
    • Focus on surveillance strategies, applied antimicrobial stewardship programs, and novel therapeutic approaches.
    • Examination of efforts to strengthen animal health systems and global awareness.

    Main Results:

    • Progress has been made in surveillance and stewardship, but obstacles remain.
    • Development of new drugs and alternatives to antimicrobials shows promise.
    • Strengthening animal health systems and increasing global awareness are crucial.

    Conclusions:

    • Continued efforts in surveillance, stewardship, and innovation are essential to combat AMR in animals.
    • Addressing AMR requires a comprehensive One Health approach, integrating human, animal, and environmental health strategies.
    • Overcoming obstacles in surveillance and stewardship is critical for effective AMR control.