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A Wet-Adhesion and Swelling-Resistant Hydrogel for Fast Hemostasis, Accelerated Tissue Injury Healing and

Kaixiang Shen1, Zhuting Lv1, Yuxuan Yang2

  • 1Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, School of Chemistry, Xi'an Jiaotong University, Xi'an, 710049, China.

Advanced Materials (Deerfield Beach, Fla.)
|December 23, 2024
PubMed
Summary

A new hydrogel adhesive (PAAS) demonstrates strong wet adhesion and swelling resistance, crucial for clinical applications. This advanced material effectively seals injuries, aids tissue repair, and monitors physiological signals, even in wet conditions.

Keywords:
bioelectronicshemostasishydrogel bioadhesivesoft tissue repairswelling resistance

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Innovation

Background:

  • Clinical need for hydrogel bioadhesives with robust wet adhesion and swelling resistance.
  • Blood and body fluids typically compromise interfacial bonding strength, leading to adhesion failure.
  • Existing bioadhesives often lack sufficient performance in challenging physiological environments.

Purpose of the Study:

  • To develop a novel hydrogel adhesive (PAAS) with superior tissue adhesion and swelling resistance for wet conditions.
  • To leverage unique chemical structures for enhanced interfacial properties and matrix stability.
  • To evaluate the efficacy of PAAS in hemostasis, tissue repair, and bioelectronic monitoring.

Main Methods:

  • Synthesis of PAAS hydrogel utilizing N-acryloyl phenylalanine for dual functionality (interfacial drainage and matrix toughening).
  • Incorporation of zwitterions to mediate electrostatic interactions for enhanced adhesion.
  • In vitro and in vivo testing on various animal models (rat, rabbit, pig) to assess adhesion strength, toughness, burst pressure, swelling ratio, hemostasis, tissue repair, and bioelectronic monitoring capabilities.

Main Results:

  • PAAS hydrogel achieved high adhesion strength (85 kPa), interfacial toughness (450 J m⁻²), and burst pressure (514 mmHg) with low swelling (<4%).
  • Demonstrated rapid hemostasis for liver, heart, and artery ruptures, and sealed pulmonary air leaks.
  • Accelerated healing of stomach and liver defects in animal models.
  • Enabled precise and durable monitoring of physiological signals (pulse, ECG, EMG) even after 3 days of water immersion.
  • Successfully evaluated in vivo sealing efficiency for artery rupture.

Conclusions:

  • PAAS hydrogel offers a promising solution for clinical hemostasis and tissue injury repair due to its exceptional wet adhesion and swelling resistance.
  • The developed hydrogel adhesive possesses versatile applications in bioelectronics, including physiological monitoring in humid environments.
  • This work presents a significant advancement in the field of hydrogel bioadhesives for demanding biomedical applications.