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Published on: April 16, 2018

Oligoadenine Strand Functionalized Polyacrylamide Hydrogel Film Exhibiting pH-Triggered High-Degree Inverse Shape

Mengyuan Yin¹, Xiaohong Hu¹, Yu Chen¹

¹Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.

Chembiochem : a European Journal of Chemical Biology

|December 23, 2024

Summary

Researchers developed smart DNA hydrogel films that rapidly change shape with pH. These oligoadenine-functionalized films show a significant inverse shape deformation, advancing flexible sensor and robot actuator technologies.

Keywords:

A-motif Biosensing Functional nucleic acids Hydrogel film Shape memory hydrogel

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Area of Science:

Materials Science
Biotechnology
Polymer Chemistry

Background:

Smart shape-memory DNA hydrogels offer tunable responses to stimuli for diverse applications.
Free-standing hydrogel films enhance deformation properties and enable visualized responses.
Existing DNA hydrogels lack rapid, high-degree inverse shape deformation capabilities.

Purpose of the Study:

To develop free-standing DNA hydrogel films with rapid and high-degree inverse shape deformation.
To investigate the mechanism of pH-induced shape change in oligoadenine-functionalized hydrogels.
To explore the potential of these hydrogels in creating advanced actuators.

Main Methods:

Fabrication of free-standing polyacrylamide hydrogel films functionalized with oligoadenine strands.
Cyclic pH treatment to induce and observe shape deformations.
Characterization of conformational transitions of oligoadenine strands and resulting hydrogel bending angles.

Main Results:

The developed hydrogel films exhibited reversible, high-degree inverse shape deformation upon cyclic pH changes.
Oligoadenine strands transitioned from flexible single strands to parallel duplex A-motif structures, acting as pH-responsive crosslinkers.
A relative bending angle change of 223.7% was achieved, significantly exceeding previous DNA hydrogel systems.
The performance was over five times greater than hydrogels utilizing i-motif structures.

Conclusions:

Oligoadenine functionalization enables rapid and significant inverse shape deformation in free-standing DNA hydrogel films.
The pH-triggered conformational switch of oligoadenine strands is key to achieving high-degree shape changes.
These advanced hydrogel films hold promise for developing next-generation bilayer actuators for flexible sensors and robots.