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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
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Polymorphisms in nanog are associated with oral leukoplakia: case-control study.
Arieli Carini Michels1, Suelen Teixeira Scheifer1, Fernanda Tiboni1
1Pontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Odontology
|December 23, 2024
Summary
This study found that NANOG gene polymorphisms are linked to oral leukoplakia. Specific NANOG gene variants increase the risk of developing this oral condition.
Area of Science:
- Genetics
- Oral Medicine
- Oncology
Background:
- Oral leukoplakia is a potentially malignant disorder.
- The role of genetic factors, including NANOG polymorphisms, in oral leukoplakia development requires further investigation.
Purpose of the Study:
- To examine the association between specific NANOG gene polymorphisms (rs877716 and rs10845877) and the risk of oral leukoplakia.
Main Methods:
- A case-control study involving 68 oral leukoplakia cases and 21 controls.
- Genotyping of NANOG tagSNPs (rs877716 and rs10845877) using real-time PCR.
- Statistical analysis using Pearson's chi-squared and Fisher's exact tests.
Main Results:
- The G allele of rs877716 (genotypes AG+GG) was significantly more frequent in oral leukoplakia cases (75.4%) than controls (50%), increasing risk by 3.063 times (p=0.031).
- The C allele of rs10845877 was more frequent in leukoplakia patients (25%) compared to controls (7.5%) (p=0.01).
- No significant association was found for other genetic models.
Conclusions:
- NANOG gene polymorphisms are associated with an increased risk of developing oral leukoplakia.
- These findings suggest NANOG may play a role in oral carcinogenesis.
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