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Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Updated: Jun 23, 2026

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[Characteristics of postmortem changes in the brain].

A I Shchegolev1, U N Tumanova1, O V Savva1,2

  • 1National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Moscow, Russia.

Sudebno-Meditsinskaia Ekspertiza
|December 23, 2024
PubMed
Summary
This summary is machine-generated.

Postmortem brain changes, like cell autolysis, begin within 20 minutes. These changes, visible through various imaging and microscopy techniques, help determine the time since death.

Keywords:
autolysisbrainpostmortem changestime since death

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Area of Science:

  • Forensic Pathology
  • Neuroscience
  • Medical Imaging

Background:

  • Understanding postmortem changes in the brain is crucial for forensic investigations.
  • The brain exhibits unique autolytic processes after death.
  • Variability in postmortem changes across different brain regions necessitates detailed analysis.

Purpose of the Study:

  • To review and analyze literature on postmortem brain alterations.
  • To evaluate the utility of these changes in estimating time since death.
  • To identify the most effective methods for visualizing postmortem brain changes.

Main Methods:

  • Literature review of studies on postmortem brain changes.
  • Analysis of data from electron microscopy, histology, histochemistry, and immunohistochemistry.
  • Evaluation of imaging techniques like postmortem CT and MRI.

Main Results:

  • Earliest signs of brain cell autolysis detected via electron microscopy at 15-20 minutes postmortem.
  • Progressive morphofunctional changes observed with increasing postmortem intervals using histological and histochemical methods.
  • Postmortem scanning identified as efficient for visualizing brain hypostases.
  • Brain autolysis impacts CT density and MRI contrast, reducing the visibility of anatomical features.

Conclusions:

  • Postmortem brain changes provide valuable indicators for determining the time since death.
  • A combination of microscopy and advanced imaging techniques offers comprehensive insights.
  • Further research can refine the accuracy of time-of-death estimations based on brain alterations.