Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Factors for Patients Under 45 Undergoing Surgery for Colorectal Liver Metastases: A SEER Population-Based Study.

Journal of surgical oncology·2026
Same author

hnRNPUL1 has a dead polynucleotide kinase domain that regulates RNA and protein interactions.

iScience·2026
Same author

Early Subspecialization Alignment: How Residents Tailor Experiences Before Fellowship.

Urology practice·2026
Same author

Lack of sustained improvements in erectile function following low-intensity extracorporeal shockwave therapy correlate with decreases in corporal brain-derived neurotropic factor: a pilot study and prospective clinical trial.

Sexual medicine·2026
Same author

Sensation kinetics identifies novel bladder sensation-capacity curve shapes during urodynamics in patients with urinary urgency.

Continence (Amsterdam, Netherlands)·2026
Same author

Phenotyping Overactive Bladder-Part 1: Are There Different Types of Urgency and Can They be Translated to Clinical, Urodynamic and Radiological Phenotyping? ICI-RS 2025.

Neurourology and urodynamics·2025

Related Experiment Video

Updated: Jun 4, 2025

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

17.7K

Comparative Neuroexcitation Patterns Using fNIRS in Women With Overactive Bladder.

Linda S Burkett, Mina Ghatas1, Helen Query

  • 1Division of Urology, Department of Surgery, Virginia Commonwealth University Health System, Richmond, VA.

Urogynecology (Philadelphia, Pa.)
|December 23, 2024
PubMed
Summary
This summary is machine-generated.

Women with overactive bladder (OAB) show lower prefrontal cortex (PFC) brain activity during high bladder sensation. This suggests reduced inhibitory control in the PFC may contribute to OAB symptoms.

More Related Videos

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.0K
Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
06:04

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: January 17, 2025

427

Related Experiment Videos

Last Updated: Jun 4, 2025

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

17.7K
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.0K
Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
06:04

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: January 17, 2025

427

Area of Science:

  • Neuroscience
  • Urology
  • Medical Imaging

Background:

  • The prefrontal cortex (PFC) is crucial for controlling the decision to void.
  • Dysfunction in the PFC has been linked to overactive bladder (OAB).
  • Functional near-infrared spectroscopy (fNIRS) offers a noninvasive method to assess PFC neuroexcitation.

Purpose of the Study:

  • To compare prefrontal cortex (PFC) neuroexcitation in female participants with and without overactive bladder (OAB).
  • To investigate PFC activity during natural bladder filling using fNIRS.

Main Methods:

  • Cross-sectional comparison of female participants with OAB and healthy controls.
  • Continuous fNIRS signal recording during an oral hydration protocol.
  • Simultaneous real-time bladder sensation monitoring and signal analysis for motion artifacts and filtering.

Main Results:

  • 14 participants with OAB and 11 controls were analyzed.
  • O2Hb levels in all PFC regions were significantly lower in the OAB group during high bladder sensation (P < 0.001).
  • OAB participants exhibited constant or decreasing neuroexcitation patterns, unlike controls who showed increasing patterns.

Conclusions:

  • Prefrontal cortex (PFC) neuroexcitation is consistently lower in women with overactive bladder (OAB) during high bladder sensation.
  • These findings support the PFC's inhibitory role in voiding control.
  • Reduced inhibitory control in the PFC may be a contributing factor to overactive bladder (OAB).