Related Experiment Video
Updated: Jul 7, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Blood loss in one-stage bilateral total knee arthroplasty: cruciate-retaining vs. posterior stabilized. A propensity
Artit Laoruengthana1, Thanawat Tantimethanon1, Nopparat Santisathaporn1
1Department of Orthopaedics, Faculty of Medicine, Naresuan University, 99 Moo 9, Phitsanulok-Nakohn Sawan Road, Mueang District, Phitsanulok, Thailand.
Introduction:
Although single-stage bilateral total knee arthroplasty (BTKA) presents several advantages, higher perioperative blood loss is a potentiate drawback that is still inevitable. Cruciate retaining (CR) TKA may theoretically result in less blood loss, offer better proprioception, and more physiologic kinematics compared to posterior stabilized (PS) TKA. The objective of this study was to compare perioperative blood loss and recovery among patients who underwent CR and PS BTKA.
Methods:
A cohort of 46 CR BTKA and 80 PS BTKA performed by a single surgeon were retrospectively evaluated. Identical surgical techniques and perioperative care were provided to all patients. Propensity score matching was utilized to compare blood loss, a visual analog scale (VAS) for postoperative pain level, morphine consumption, knee flexion arc, and length of stay (LOS).
Results:
Comparing CR BTKA and PS BTKA, drain output was 206.44 mL vs. 194.89 mL (p = 0.47), calculated blood loss was 886.23 mL vs. 724.89 mL (p = 0.05), and blood transfusion rate was 18% vs. 17% (p = 1.00). Additionally, CR BTKA had higher VAS than PS BTKA, at 6 h: 5.74 vs. 3.78 (p < 0.001), and at 12 h: 5.80 vs. 4.74 (p = 0.02). CR BTKA group had higher morphine consumption (26.87 mg vs. 19.74 mg; p = 0.01) in the first 48 h. CR BTKA showed significantly less knee flexion angle during 48-72 h postoperative.
Conclusions:
The use of the CR prosthesis in BTKA could not demonstrate a superiority over the PS design in terms of blood loss, and recovery of knee function during the acute postoperative period.

