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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
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LONG-TERM FUNCTIONAL AND CLINICAL OUTCOMES IN FAMILIAL EXUDATIVE VITREORETINOPATHY.

Hongan Chen1, Anne Strong Caldwell1, Jennifer L Patnaik1

  • 1Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado.

Retina (Philadelphia, Pa.)
|December 23, 2024
PubMed
Summary

Familial exudative vitreoretinopathy patients demonstrate good long-term vision. Most patients maintained functional and ambulatory vision, with a high rate of globe salvage.

Keywords:
FEVRfamilial exudative vitreoretinopathyfunctional visioninherited retinal diseasepediatric retina

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Area of Science:

  • Ophthalmology
  • Genetics

Background:

  • Familial exudative vitreoretinopathy (FEVR) is a rare genetic disorder affecting retinal vascular development.
  • Understanding long-term outcomes is crucial for patient management and genetic counseling.

Purpose of the Study:

  • To characterize long-term functional and anatomical outcomes in patients diagnosed with familial exudative vitreoretinopathy (FEVR).

Main Methods:

  • Retrospective chart review of FEVR patients from January 2003 to January 2024.
  • Data collected included demographics, clinical findings, and visual acuity.
  • Functional vision defined as Snellen visual acuity ≥20/40; ambulatory vision as ≥20/200.

Main Results:

  • 96 patients (186 eyes) with FEVR identified; 46 patients (90 eyes) analyzed.
  • Average follow-up was 9.1 years.
  • 77.3% achieved functional vision, 88.6% achieved ambulatory vision.
  • Globe salvage rate was 98.4%.
  • Retinal detachment at presentation was linked to worse vision.

Conclusions:

  • FEVR patients exhibit favorable long-term visual outcomes.
  • Over 75% achieved functional vision (≥20/40).
  • Nearly 89% avoided legal blindness (≥20/200).