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Related Experiment Videos

Natural killer cell activity in asthma.

T Timonen, B Stenius-Aarniala

    Clinical and Experimental Immunology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Asthma patients show increased natural killer (NK) cell activity, primarily due to a higher number of large granular lymphocytes (LGL) in their blood, not enhanced individual cell function.

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    Area of Science:

    • Immunology
    • Allergy and Asthma Research
    • Cellular Immunology

    Background:

    • Natural killer (NK) cells are crucial for innate immunity.
    • NK cell activity may be altered in inflammatory conditions like asthma.
    • Understanding NK cell function in asthma is important for immune response insights.

    Purpose of the Study:

    • To investigate peripheral blood NK cell activity in asthma patients.
    • To identify the specific immune cells mediating NK activity in asthma.
    • To determine whether increased NK activity is due to cell frequency or individual cell function.

    Main Methods:

    • Analysis of peripheral blood NK activity in 32 asthma patients and 13 controls.
    • NK activity was measured against the K-562 leukaemic cell line.

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  • Mononuclear cells were fractionated using discontinuous density gradient centrifugation.

    • Main Results:

    • Asthma patients, particularly males and females with atopic asthma, exhibited significantly higher NK activity.
    • Large granular lymphocytes (LGL) were identified as the primary mediators of NK activity in asthmatics.
    • Increased NK activity in asthma is attributed to a greater frequency of LGL, not enhanced individual NK cell potency.

    Conclusions:

    • Peripheral blood NK activity is enhanced in asthma patients.
    • The increased NK activity is predominantly mediated by a higher number of LGL.
    • This finding suggests a distinct role for LGL in the immune response of asthma.