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Updated: May 8, 2025

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

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Intergenerational risk of preterm birth in First Nations Australians: a population-based cohort study from the

Holger W Unger1,2,3,4,5, Abel Dadi6,7, Kiarna Brown6,8

  • 1Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia. holger.unger@menzies.edu.au.

BMC Pregnancy and Childbirth
|December 23, 2024
PubMed

Insights

First Nations women born preterm face a higher risk of early preterm birth (PTB). Conditions like pre-eclampsia partially explain this intergenerational PTB recurrence, suggesting targeted preventative care is needed.

Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Indigenous Health

Background:

  • Preterm birth (PTB) is linked to long-term health issues, with higher rates among First Nations babies in Australia's Northern Territory (NT).
  • Understanding intergenerational PTB recurrence is crucial for developing effective public health strategies in the NT.

Purpose of the Study:

  • To assess the magnitude of intergenerational PTB recurrence in the NT.
  • To identify potential drivers of PTB recurrence, particularly among First Nations women.

Main Methods:

  • A retrospective cohort study analyzed 9,571 births from 5,366 mothers (1986-2017) in the NT.
  • Modified Poisson regression estimated the relative risk of PTB associated with maternal PTB, adjusting for covariates.
  • Mediation analysis explored the role of conditions like pre-eclampsia in PTB recurrence.

Main Results:

  • First Nations women born preterm had a significantly increased risk of delivering preterm (aRR 1.28).
  • Early PTB in mothers was associated with a higher risk of early PTB in offspring (aRR 1.95).
  • Pre-eclampsia, intrauterine growth restriction, and hypertensive renal disease partially mediated this association, accounting for up to 26% of recurrence.

Conclusions:

  • First Nations women born preterm are at increased risk for early PTB, influenced by conditions such as pre-eclampsia.
  • Identifying mothers with a history of PTB can help target preventative interventions for NT First Nations women.
  • Maternal PTB history did not correlate with PTB in non-First Nations women in this study.
Abstract

Keywords:
Early preterm birthFirst NationsIntergenerationalPreterm birth

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