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Related Concept Videos

Colloids and Suspensions01:17

Colloids and Suspensions

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Cosmetic emulsions containing innovative complex coacervates: A cross-sectional study.

Delaporte Adeline1, Grisel Michel1, Gore Ecaterina1

  • 1Normandie Univ, URCOM UR 3221, Université Le Havre Normandi, Le Havre, France.

International Journal of Cosmetic Science
|December 24, 2024
PubMed
Summary

Sustainable biopolymers successfully encapsulated Vitamin E (α-tocopherol) in microcapsules, enhancing cosmetic emulsion properties. These novel coacervates offer improved stability and texture for advanced skincare formulations.

Keywords:
complex coacervationemulsionsencapsulationpolymersstabilityα‐tocopherol

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Area of Science:

  • Cosmetic Science
  • Materials Science
  • Biotechnology

Background:

  • Vitamin E (α-tocopherol) is a vital lipophilic antioxidant for topical use.
  • Challenges include its poor solubility and sensitivity to degradation in formulations.
  • Encapsulation is key to overcoming these limitations for effective skincare.

Purpose of the Study:

  • To develop sustainable, non-animal microcapsules for Vitamin E using complex coacervation.
  • To evaluate the impact of these microcapsules on cosmetic emulsion properties and stability.
  • To explore fungal chitosan and gum Arabic as biopolymer alternatives.

Main Methods:

  • Vitamin E (α-tocopherol) was encapsulated using complex coacervation with fungal chitosan and gum Arabic.
  • Microcapsules were incorporated into oil-in-water cosmetic emulsions.
  • Physicochemical properties and stability of emulsions with and without encapsulated Vitamin E were assessed.

Main Results:

  • Successfully developed microcapsules with high encapsulation efficiency (87.0%) and loading (27.2%).
  • Microcapsules demonstrated excellent thermal stability (up to 220°C) and improved storage stability for Vitamin E.
  • Emulsions with microcapsules exhibited enhanced viscosity, viscoelasticity, and textural properties, remaining stable over time.

Conclusions:

  • Fungal chitosan-gum Arabic coacervates are a viable, sustainable alternative for encapsulating lipophilic actives.
  • The developed microcapsules significantly improve the textural and rheological characteristics of cosmetic emulsions.
  • This technology holds promise for creating advanced skincare products with enhanced functional benefits and stability.