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Updated: Jun 4, 2025
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples
Md Kaisar Rahman1, Babafela Awosile1
1Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, USA.
Background:
This study aimed to explore the distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples.
Methods:
We analyzed data from 83 countries through the Antimicrobial Testing Leadership and Surveillance program, spanning 2004 to 2021. We calculated the proportion of each β-lactamase gene across nine bacterial species and generated a heatmap for β-lactamase genes with a frequency of ≥ 1 % in at least one species.
Results:
A total of 359 β-lactamase genes were identified, with the highest proportion found in Klebsiella spp. (61.84 %, n = 222), followed by Escherichiacoli (47.63 %, n = 171), and Proteus spp. (20.61 %, n = 74). The ESBL gene blaCTX-M-15 was most prevalent in Klebsiella spp. (62.39 %) and E.coli (53.16 %). The carbapenemase genes blaNDM-1, blaOXA-48, and blaKPC-2 were notably higher in Providencia spp. (59.47 %), Raoultella spp. (45.45 %), and Serratia spp. (25.24 %), respectively.
Conclusion:
Further surveillance and research are needed to investigate the diversity of β-lactamase genes across One Health interfaces.
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