Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calmodulin levels in hypertensive rats.

J Higaki, T Ogihara, Y Kumahara

    Clinical Science (London, England : 1979)
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Usefulness of the renal resistive index to predict an increase in urinary albumin excretion in patients with essential hypertension.

    Journal of human hypertension·2016
    Same author

    Angiotensin II receptor blockade with valsartan decreases plasma osteopontin levels in patients with essential hypertension.

    Journal of human hypertension·2010
    Same author

    Clinical utility of temozolomide in the treatment of malignant paraganglioma: a preliminary report.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2009
    Same author

    Determinants of left ventricular untwisting behaviour in patients with dilated cardiomyopathy: analysis by two-dimensional speckle tracking.

    Heart (British Cardiac Society)·2008
    Same author

    Possible link between large artery stiffness and coronary flow velocity reserve.

    Heart (British Cardiac Society)·2007
    Same author

    Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2007

    Intracellular calmodulin levels, a key calcium regulator, were lower in the brains and organs of spontaneously hypertensive rats. This suggests a genetic disruption but may not be the primary cause of hypertension.

    Area of Science:

    • Biochemistry
    • Physiology
    • Hypertension Research

    Background:

    • Intracellular calcium regulation is crucial for various physiological processes.
    • Calmodulin is a key calcium-binding protein involved in cellular signaling.
    • Hypertension involves complex dysregulation of cellular functions.

    Purpose of the Study:

    • To investigate intracellular calmodulin levels in spontaneously hypertensive rats (SHR) compared to Wistar-Kyoto rats (WKY).
    • To examine the role of calmodulin in the development of hypertension.
    • To assess calmodulin levels in different organs, including the brain, heart, aorta, and kidney.

    Main Methods:

    • Direct radioimmunoassay was used to quantify intracellular calmodulin levels.
    • Measurements were performed in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY).

    Related Experiment Videos

  • Calmodulin levels were also assessed in deoxycorticosterone acetate (DOCA)-salt induced hypertensive rats.

    • Main Results:

    • Spontaneously hypertensive rats (SHR) exhibited decreased calmodulin levels in the brain, heart, aorta, and kidney compared to Wistar-Kyoto rats (WKY).
    • Deoxycorticosterone acetate (DOCA)-salt rats showed reduced calmodulin levels in the brain but not in the heart, aorta, or kidney.
    • These findings indicate a potential genetic disruption in calcium-dependent regulatory systems in SHR.

    Conclusions:

    • Intracellular calmodulin levels are significantly reduced in multiple organs of spontaneously hypertensive rats.
    • While calmodulin levels are altered, this disruption is likely not a primary factor in the development of hypertension.
    • Further research into calcium-dependent regulatory systems is warranted for understanding hypertension.